2012 Major game schedule
| Game # | Date | Visitor | Home | Location | Time |
|---|
| 401 | 2012-02-28 | Yankees | Rangers | MAJ | 4:15 |
| 402 | 2012-02-29 | Tigers | Cardinals | MAJ | 4:15 |
| 403 | 2012-03-01 | Angels | Dodgers | MAJ | 4:15 |
| 404 | 2012-03-03 | Dodgers | Tigers | MAJ | 3:00 |
| 405 | 2012-03-03 | Rangers | Angels | MAJ | 12:00 |
| 406 | 2012-03-03 | Cardinals | Yankees | MAJ | 9:00 |
| 407 | 2012-03-06 | Rangers | Dodgers | MAJ | 4:15 |
| 408 | 2012-03-07 | Yankees | Tigers | MAJ | 4:15 |
| 409 | 2012-03-08 | Angels | Cardinals | MAJ | 4:15 |
| 410 | 2012-03-10 | Dodgers | Yankees | MAJ | 9:00 |
| 411 | 2012-03-10 | Cardinals | Rangers | MAJ | 12:00 |
| 412 | 2012-03-10 | Tigers | Angels | MAJ | 3:00 |
| 413 | 2012-03-13 | Dodgers | Cardinals | MAJ | 5:00 |
| 414 | 2012-03-14 | Angels | Yankees | MAJ | 5:00 |
| 415 | 2012-03-15 | Rangers | Tigers | MAJ | 5:00 |
| 416 | 2012-03-17 | Angels | Dodgers | MAJ | 9:00 |
| 417 | 2012-03-17 | Cardinals | Tigers | MAJ | 12:00 |
| 418 | 2012-03-17 | Rangers | Yankees | MAJ | 3:00 |
| 419 | 2012-03-20 | Tigers | Dodgers | MAJ | 5:00 |
| 420 | 2012-03-21 | Angels | Rangers | MAJ | 5:00 |
| 421 | 2012-03-22 | Cardinals | Yankees | MAJ | 5:00 |
| 422 | 2012-03-24 | Dodgers | Rangers | MAJ | 3:00 |
| 423 | 2012-03-24 | Tigers | Yankees | MAJ | 12:00 |
| 424 | 2012-03-24 | Angels | Cardinals | MAJ | 9:00 |
| 425 | 2012-03-27 | Dodgers | Yankees | MAJ | 5:00 |
| 426 | 2012-03-28 | Rangers | Cardinals | MAJ | 5:00 |
| 427 | 2012-03-29 | Angels | Tigers | MAJ | 5:00 |
| 428 | 2012-03-31 | Cardinals | Dodgers | MAJ | 9:00 |
| 429 | 2012-03-31 | Yankees | Angels | MAJ | 12:00 |
| 430 | 2012-03-31 | Tigers | Rangers | MAJ | 3:00 |
| 431 | 2012-04-03 | Dodgers | Angels | MAJ | 5:00 |
| 432 | 2012-04-04 | Tigers | Cardinals | MAJ | 5:00 |
| 433 | 2012-04-05 | Yankees | Rangers | MAJ | 5:00 |
| 434 | 2012-04-07 | Dodgers | Tigers | MAJ | 3:00 |
| 435 | 2012-04-07 | Rangers | Angels | MAJ | 12:00 |
| 436 | 2012-04-07 | Yankees | Cardinals | MAJ | 9:00 |
| 437 | 2012-04-17 | Rangers | Dodgers | MAJ | 5:00 |
| 438 | 2012-04-18 | Yankees | Tigers | MAJ | 5:00 |
| 439 | 2012-04-19 | Cardinals | Angels | MAJ | 5:00 |
| 440 | 2012-04-21 | Yankees | Dodgers | MAJ | 9:00 |
| 441 | 2012-04-21 | Cardinals | Rangers | MAJ | 12:00 |
| 442 | 2012-04-21 | Angels | Tigers | MAJ | 3:00 |
| 443 | 2012-04-24 | Cardinals | Dodgers | MAJ | 5:00 |
| 444 | 2012-04-25 | Angels | Yankees | MAJ | 5:00 |
| 445 | 2012-04-26 | Tigers | Rangers | MAJ | 5:00 |
| 446 | 2012-04-28 | Dodgers | Angels | MAJ | 9:00 |
| 447 | 2012-04-28 | Cardinals | Tigers | MAJ | 12:00 |
| 448 | 2012-04-28 | Rangers | Yankees | MAJ | 3:00 |
| 449 | 2012-05-01 | Tigers | Dodgers | MAJ | 5:00 |
| 450 | 2012-05-02 | Rangers | Angels | MAJ | 5:00 |
| 451 | 2012-05-03 | Yankees | Cardinals | MAJ | 5:00 |
| 452 | 2012-05-05 | Dodgers | Rangers | MAJ | 3:00 |
| 453 | 2012-05-05 | Tigers | Yankees | MAJ | 12:00 |
| 454 | 2012-05-05 | Angels | Cardinals | MAJ | 9:00 |
| 455 | 2012-05-08 | Tigers | Angels | MAJ | 5:00 |
| 456 | 2012-05-09 | Rangers | Cardinals | MAJ | 5:00 |
| 457 | 2012-05-10 | Yankees | Dodgers | MAJ | 5:00 |
| 458 | 2012-05-12 | Yankees | Angels | MAJ | 9:00 |
| 459 | 2012-05-12 | Rangers | Tigers | MAJ | 3:00 |
| 460 | 2012-05-12 | Dodgers | Cardinals | MAJ | 12:00 |