Majors game schedule
| Game | Date | Visitor | Score | Home | Score |
|---|
| 401 | 2010-04-26 | A's | 4 | Dodgers | 17 |
| 402 | 2010-02-27 | Cardinals | 3 | Angels | 2 |
| 403 | 2010-02-27 | Yankees | 5 | Indians | 14 |
| 404 | 2010-03-02 | Dodgers | 5 | Cardinals | 4 |
| 405 | 2010-03-03 | A's | 4 | Yankees | 6 |
| 406 | 2010-03-04 | Indians | 2 | Angels | 0 |
| 407 | 2010-03-06 | Indians | 8 | A's | 6 |
| 408 | 2010-03-06 | Yankees | 7 | Cardinals | 6 |
| 409 | 2010-03-06 | Angels | 3 | Dodgers | 10 |
| 410 | 2010-03-09 | Cardinals | 1 | Indians | 14 |
| 411 | 2010-03-10 | Angels | 15 | A's | 1 |
| 412 | 2010-03-11 | Dodgers | 6 | Yankees | 0 |
| 413 | 2010-03-13 | Yankees | 4 | Angels | 12 |
| 414 | 2010-03-13 | Dodgers | 1 | Indians | 6 |
| 415 | 2010-03-13 | A's | 4 | Cardinals | 11 |
| 416 | 2010-03-16 | Dodgers | 13 | A's | 2 |
| 417 | 2010-03-17 | Indians | 15 | Yankees | 1 |
| 418 | 2010-03-18 | Angels | 7 | Cardinals | 0 |
| 419 | 2010-03-20 | Cardinals | 1 | Dodgers | 3 |
| 420 | 2010-03-20 | Yankees | 8 | A's | 4 |
| 421 | 2010-03-20 | Angels | 0 | Indians | 3 |
| 422 | 2010-03-23 | Dodgers | 0 | Angels | 6 |
| 423 | 2010-03-24 | Cardinals | 4 | Yankees | 5 |
| 424 | 2010-03-25 | A's | 0 | Indians | 1 |
| 425 | 2010-03-27 | Indians | 23 | Cardinals | 11 |
| 426 | 2010-03-27 | A's | 1 | Angels | 6 |
| 427 | 2010-03-27 | Yankees | 3 | Dodgers | 12 |
| 428 | 2010-03-30 | Angels | 10 | Yankees | 2 |
| 429 | 2010-03-31 | Indians | 4 | Dodgers | 1 |
| 430 | 2010-04-01 | Cardinals | 11 | A's | 3 |
| 431 | 2010-04-13 | Yankees | 2 | Indians | 6 |
| 432 | 2010-04-14 | A's | 1 | Dodgers | 3 |
| 433 | 2010-04-15 | Cardinals | 5 | Angels | 3 |
| 434 | 2010-04-17 | A's | 7 | Yankees | 8 |
| 435 | 2010-04-17 | Indians | 4 | Angels | 1 |
| 436 | 2010-04-17 | Dodgers | 7 | Cardinals | 2 |
| 437 | 2010-05-03 | Indians | 7 | A's | 3 |
| 438 | 2010-04-21 | Yankees | 4 | Cardinals | 5 |
| 439 | 2010-04-22 | Angels | 3 | Dodgers | 1 |
| 440 | 2010-04-24 | Cardinals | 3 | Indians | 9 |
| 441 | 2010-04-24 | Angels | 7 | A's | 2 |
| 442 | 2010-04-24 | Dodgers | 6 | Yankees | 7 |
| 443 | 2010-04-27 | Yankees | 1 | Angels | 8 |
| 444 | 2010-04-28 | A's | 3 | Cardinals | 1 |
| 445 | 2010-04-29 | Dodgers | 3 | Indians | 4 |
| 446 | 2010-05-01 | Indians | 2 | Yankees | 1 |
| 447 | 2010-05-01 | Dodgers | 6 | A's | 1 |
| 448 | 2010-05-01 | Angels | 11 | Cardinals | 4 |
| 449 | 2010-05-04 | Cardinals | 5 | Dodgers | 6 |
| 450 | 2010-05-05 | Angels | 1 | Indians | 0 |
| 451 | 2010-05-06 | Yankees | 4 | A's | 6 |
| 452 | 2010-05-08 | Dodgers | 2 | Angels | 3 |
| 453 | 2010-05-08 | Cardinals | 6 | Yankees | 3 |
| 454 | 2010-05-08 | A's | 3 | Indians | 5 |